A new study by Yanase and colleagues in the Journal Critical Care Medicine has shed some light on what has been a topic of conversation in our Intensive Care Units; Is Vitamin C safe to consider using in some of the patient populations that we have considered recently, namely septic shock or possibly COVID-19. The answer, of course with the usual patient specific caveats, such as attention to hypernatremia, G6PD deficiency, glucometer reading errors, and oxalate nephropathy, appears to be yes.

Interestingly, since Vitamin C is coupled with thiamine as per the Marik protocol, this coupling may actually further the safety profile of Vitamin C as thiamine hinders the production of oxalate, which is a metabolite of Vitamin C, hence further decreasing the risk of oxalate nephropathy.

You can read the original paper here:

https://journals.lww.com/ccmjournal/Abstract/2020/07000/Harm_of_IV_High_Dose_Vitamin_C_Therapy_in_Adult.38.aspx